Biomarker quantification by mass spectrometry

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Resource Type

Properties

1. Fee for service

   Yes

2. Resource Description

   "Rigorous quantification of serum, plasma or urinary biomarkers identified by metabolomics studies can be conducted using stable isotope dilution LC-SRM/MS methodology as described by Ciccimaro and Blair (Bioanalysis. 2010;2:311-341)."

3. Related Resource

   Thermo Scientific TSQ Vantage triple quadrupole mass spectrometer with Waters nanoAcquity UPLC system

4. Related Resource

   Thermo Scientific LTQ-XL ion trap mass spectrometer with Eksigent NanoLC system

5. Related Resource

   Thermo TSQ Quantum Ultra triple quadrupole mass spectrometer with Waters 2690 Alliance series HPLC system

6. Related Resource

   Agilent 6460 triple quadrupole mass spectrometer with Agilent 1200 HPLC system

7. Service Provided by

   Translational Biomarker Core (Penn)

8. Related Publication or Documentation

   Stable-isotope dilution LC–MS for quantitative biomarker analysis

9. Related Publication or Documentation

   8-Oxo-2'-deoxyguanosine as a biomarker of tobacco-smoking-induced oxidative stress

10. Related Publication or Documentation

    Quantification of key red blood cell folates from subjects with defined MTHFR 677C>T genotypes using stable isotope dilution liquid chromatography/mass spectrometry

11. Related Technique

    Liquid chromatography-mass spectrometry