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K14-Cdx2 mice

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013a-9969-75c2-d69a-d90d80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Using the <i>Keratin-14</i> gene promoter, Cdx2 (<i>Caudal</i>-related transcription factor) mRNA and protein expression are induced in the basal cell layer of squamous epithelium of these mice. Cdx2 expression was detected in the skin as well as the esophagus and forestomach.
  2. Additional Name
    K14-Cdx2
  3. Related Disease
    Barrett's esophagus
  4. Related Publication or Documentation
    Ectopic Cdx2 Expression in Murine Esophagus Models an Intermediate Stage in the Emergence of Barrett’s Esophagus
  5. Parental Strain Name
    BGSJL/F1
  6. Parental Strain Name
    C57BL/6
  7. Parental Strain Name
    CD-1
  8. Parental Strain Name
    FVB/N
  9. Genetic Alteration(s)
    K14-Cdx2 insertion
  10. Phenotype Findings
    Altered esophagus epithelium function
  11. Phenotype Findings
    Reduced proliferation of cultured transgenic keratinocytes
  12. Phenotype Findings
    Altered basal cell morphology and ultrastructure in esophagus and fore stomach
  13. Location
    John Lynch Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2012-10-25T16:32:06.537-04:00
  4. creator
    fcoldren
  5. modified
    2012-11-19T16:01:27.102-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016