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Systemic Akt2 KO and liver-specific Akt1 KO

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013a-bcaf-3f43-d69a-d90d80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Akt1<sup>loxP/loxP</sup>;Akt2<sup>−/−</sup> mice were bred to Afp–Cre mice. Afp-Cre mice express Cre recombinase specifically in the liver.
  2. Additional Name
    Akt2<sup>-/-</sup>;Akt1<sup>loxP/loxP</sup>;Afp-Cre
  3. Related Disease
    hyperglycemia
  4. Related Disease
    type 2 diabetes mellitus
  5. Related Publication or Documentation
    Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
  6. Genetic Alteration(s)
    Akt2[tm1.1Mbb]
  7. Genetic Alteration(s)
    AlfpCre insertion
  8. Genetic Alteration(s)
    Floxed Akt1
  9. Phenotype Findings
    Severe hyperglycemia
  10. Phenotype Findings
    Foxo1 activation in liver
  11. Location
    Birnbaum Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2012-11-01T13:37:18.577-04:00
  4. creator
    fcoldren
  5. modified
    2013-02-18T16:44:35.879-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016