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Liver-specific Akt1 and Akt2 knockout

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013a-bd0c-a849-d69a-d90d80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    The liver-specific Akt1;Akt2 KO mice were created by injecting Akt1<sup>loxP/loxP</sup>;Akt2 <sup>loxP/loxP</sup> mice with adeno-associated virus expressing Cre recombinase under the control of the Tbg promoter (AAV-Tbg-Cre).
  2. Additional Name
    DLKO
  3. Related Disease
    type 2 diabetes mellitus
  4. Related Publication or Documentation
    Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
  5. Parental Strain Name
    C57BL6
  6. Genetic Alteration(s)
    Akt2[tm1Mbb]
  7. Genetic Alteration(s)
    Floxed Akt1
  8. Phenotype Findings
    Hyperglycemia, glucose intolerance and insulin resistance
  9. Phenotype Findings
    Disrupted expression of Foxo1-regulated genes in the liver
  10. Phenotype Findings
    Insulin signaling defects
  11. Location
    Birnbaum Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2012-11-01T13:54:39.523-04:00
  4. creator
    fcoldren
  5. modified
    2013-01-29T15:19:17.142-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016