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PGI2 Receptor Knockout Mouse
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013a-c1be-84b1-d69a-d90d80000000
Resource Type
Mus musculus
Properties
Resource Description
The IPKO mice were generated by homologous recombination in embryonic stem (ES) cells.
Additional Name
IP KO Mouse
Contact
FitzGerald, Garret, M.D.
Related Disease
cardiovascular system disease
Related Disease
viral infectious disease
Related Publication or Documentation
Role of Prostacyclin in the Cardiovascular Response to Thromboxane A2
Related Publication or Documentation
Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice
Related Publication or Documentation
Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation
Related Publication or Documentation
Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness
Related Publication or Documentation
COX-2 derived prostacyclin modulates vascular remodeling
Genetic Alteration(s)
IP KO
Phenotype Findings
Proliferative response to vascular injury
Phenotype Findings
Enhanced thrombus formation
Location
FitzGerald Lab
Inferred Types from the eagle-i Ontology (
What is an ontology?
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entity
continuant
independent_continuant
material_entity
Organism
Mus <mouse, genus>
Glires
Mammalia
Chordata
Vertebrata <Metazoa>
Rodentia
Organism or Virus
Thing
Provenance Metadata About This Resource Record
workflow owner
sarahtee (Sarah Teegarden)
workflow state
Published
contributor
sarahtee (Sarah Teegarden)
created
2012-11-02T11:48:15.024-04:00
creator
sarahtee (Sarah Teegarden)
modified
2013-01-18T11:27:34.833-05:00
The University of PennsylvaniaThe University of Pennsylvania
