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Vascular COX-2 Knockout Mouse
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013a-d171-cd83-d69a-d90d80000000
Resource Type
Properties
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Resource Description
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Mice with the COX-2 gene flanked with two LoxP sites were crossed with mice expressing SM22-Cre (vascular smooth muscle cells) or Tie2-Cre (endothelial cells). Double knockout mice lacking COX-2 in both vascular cell types were produced by crossing these two lines together.
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Contact
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Teegarden, Sarah., PhD
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Related Publication or Documentation
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Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice
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Biological process studied
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Biological regulation
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Genetic Alteration(s)
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Floxed COX-2
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Genetic Alteration(s)
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SM22-Cre
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Genetic Alteration(s)
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Tie2-Cre
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Phenotype Findings
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Elevated blood pressure and thrombogenesis
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Location
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FitzGerald Lab
