Vascular COX-2 Knockout Mouse

eagle-i ID

Resource Type

Properties

1. Resource Description

   Mice with the COX-2 gene flanked with two LoxP sites were crossed with mice expressing SM22-Cre (vascular smooth muscle cells) or Tie2-Cre (endothelial cells). Double knockout mice lacking COX-2 in both vascular cell types were produced by crossing these two lines together.

2. Contact

   Teegarden, Sarah, Ph.D.

3. Related Publication or Documentation

   Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice

4. Biological process studied

   Biological regulation

5. Genetic Alteration(s)

   Floxed COX-2

6. Genetic Alteration(s)

   SM22-Cre

7. Genetic Alteration(s)

   Tie2-Cre

8. Phenotype Findings

   Elevated blood pressure and thrombogenesis

9. Location

   FitzGerald Lab