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Vascular COX-2 Knockout Mouse

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013a-d171-cd83-d69a-d90d80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Mice with the COX-2 gene flanked with two LoxP sites were crossed with mice expressing SM22-Cre (vascular smooth muscle cells) or Tie2-Cre (endothelial cells). Double knockout mice lacking COX-2 in both vascular cell types were produced by crossing these two lines together.
  2. Contact
    Teegarden, Sarah, Ph.D.
  3. Related Publication or Documentation
    Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice
  4. Biological process studied
    Biological regulation
  5. Genetic Alteration(s)
    Floxed COX-2
  6. Genetic Alteration(s)
    SM22-Cre
  7. Genetic Alteration(s)
    Tie2-Cre
  8. Phenotype Findings
    Elevated blood pressure and thrombogenesis
  9. Location
    FitzGerald Lab
 
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016