COX-1 Knockdown Mouse

eagle-i ID

Resource Type

Properties

1. Resource Description

   A neomycin resistance cassette was inserted into the middle of intron 10 of the PGHS1 (COX-1) gene by targeting in embryonic stem cells. Insertion of this cassette within intronic sequences has previously been shown to generate a hypomorphic allele or knockdown of gene expression to very low levels.

2. Additional Name

   COX-1 neo

3. Additional Name

   PGHS1 Knockdown

4. Additional Name

   PGHS1 neo

5. Contact

   Teegarden, Sarah, Ph.D.

6. Related Disease

   cardiovascular system disease

7. Related Publication or Documentation

   Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition

8. Related Publication or Documentation

   Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function

9. Related Publication or Documentation

   Niacin and biosynthesis of PGD2 by platelet COX-1 in mice and humans

10. Parental Strain Name

    C57BL/6 × 129/Sv

11. Genetic Alteration(s)

    COX-1 neo

12. Phenotype Findings

    Reduced COX-1 expression

13. Phenotype Findings

    Reduced inflammatory response

14. Phenotype Findings

    Platelet aggregation, bleeding, and thrombosis

15. Phenotype Findings

    Blood pressure

16. Location

    FitzGerald Lab