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COX-1 Knockdown Mouse

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013a-e08b-4986-e44e-976d80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    A neomycin resistance cassette was inserted into the middle of intron 10 of the PGHS1 (COX-1) gene by targeting in embryonic stem cells. Insertion of this cassette within intronic sequences has previously been shown to generate a hypomorphic allele or knockdown of gene expression to very low levels.
  2. Additional Name
    COX-1 neo
  3. Additional Name
    PGHS1 Knockdown
  4. Additional Name
    PGHS1 neo
  5. Contact
    Teegarden, Sarah, Ph.D.
  6. Related Disease
    cardiovascular system disease
  7. Related Publication or Documentation
    Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition
  8. Related Publication or Documentation
    Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
  9. Related Publication or Documentation
    Niacin and biosynthesis of PGD2 by platelet COX-1 in mice and humans
  10. Parental Strain Name
    C57BL/6 × 129/Sv
  11. Genetic Alteration(s)
    COX-1 neo
  12. Phenotype Findings
    Reduced COX-1 expression
  13. Phenotype Findings
    Reduced inflammatory response
  14. Phenotype Findings
    Platelet aggregation, bleeding, and thrombosis
  15. Phenotype Findings
    Blood pressure
  16. Location
    FitzGerald Lab
 
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Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016