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Macrophage COX-2 Knockout Mouse

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013a-e5ce-bbd1-e44e-976d80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Mice with the COX-2 gene flanked with two LoxP sites were crossed with LysM-Cre mice to delete COX-2 in myeloid cells, including macrophages, neutrophils, and some dendritic cells.
  2. Additional Name
    LysM-Cre / COX-2 Knockout mouse
  3. Contact
    Teegarden, Sarah, Ph.D.
  4. Related Publication or Documentation
    Targeted Deletions of Cyclooxygenase-2 and Atherogenesis in Mice
  5. Biological process studied
    Immune system process
  6. Genetic Alteration(s)
    Floxed COX-2
  7. Genetic Alteration(s)
    Lyz2[tm1(cre)Ifo]
  8. Phenotype Findings
    Prostanoid response to lipopolysaccharide
  9. Location
    FitzGerald Lab
 
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Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016