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Macrophage COX-2 Knockout / LDLR Knockout Mouse
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013a-e5da-20c7-e44e-976d80000000
Resource Type
Properties
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Resource Description
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Mice with the COX-2 gene flanked by two LoxP sites were crossed with mice expressing LysM Cre (Cre recombinase in myeloid cells). These mice were then crossed with LDLR knockout mice (The Jackson Laboratory, Bar Harbor, ME).
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Additional Name
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LysM-Cre COX-2 KO / LDLR KO
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Contact
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Teegarden, Sarah., PhD
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Related Disease
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cardiovascular system disease
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Related Publication or Documentation
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Targeted Deletions of Cyclooxygenase-2 and Atherogenesis in Mice
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Genetic Alteration(s)
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Floxed COX-2
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Genetic Alteration(s)
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LDLR Knockout
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Genetic Alteration(s)
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Lyz2[tm1(cre)Ifo]
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Phenotype Findings
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Reduced atherogenesis
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Location
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FitzGerald Lab
