Macrophage COX-2 Knockout / LDLR Knockout Mouse

eagle-i ID

Resource Type

Properties

1. Resource Description

   Mice with the COX-2 gene flanked by two LoxP sites were crossed with mice expressing LysM Cre (Cre recombinase in myeloid cells). These mice were then crossed with LDLR knockout mice (The Jackson Laboratory, Bar Harbor, ME).

2. Additional Name

   LysM-Cre COX-2 KO / LDLR KO

3. Contact

   Teegarden, Sarah, Ph.D.

4. Related Disease

   cardiovascular system disease

5. Related Publication or Documentation

   Targeted Deletions of Cyclooxygenase-2 and Atherogenesis in Mice

6. Genetic Alteration(s)

   Floxed COX-2

7. Genetic Alteration(s)

   LDLR Knockout

8. Genetic Alteration(s)

   Lyz2[tm1(cre)Ifo]

9. Phenotype Findings

   Reduced atherogenesis

10. Location

    FitzGerald Lab