eagle-i The University of PennsylvaniaThe University of Pennsylvania
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Macrophage COX-2 Knockout / LDLR Knockout Mouse

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013a-e5da-20c7-e44e-976d80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Mice with the COX-2 gene flanked by two LoxP sites were crossed with mice expressing LysM Cre (Cre recombinase in myeloid cells). These mice were then crossed with LDLR knockout mice (The Jackson Laboratory, Bar Harbor, ME).
  2. Additional Name
    LysM-Cre COX-2 KO / LDLR KO
  3. Contact
    Teegarden, Sarah, Ph.D.
  4. Related Disease
    cardiovascular system disease
  5. Related Publication or Documentation
    Targeted Deletions of Cyclooxygenase-2 and Atherogenesis in Mice
  6. Genetic Alteration(s)
    Floxed COX-2
  7. Genetic Alteration(s)
    LDLR Knockout
  8. Genetic Alteration(s)
    Lyz2[tm1(cre)Ifo]
  9. Phenotype Findings
    Reduced atherogenesis
  10. Location
    FitzGerald Lab
 
RDFRDF
 
Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016