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Macrophage COX-2 Knockout / LDLR Knockout Mouse

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    Mice with the COX-2 gene flanked by two LoxP sites were crossed with mice expressing LysM Cre (Cre recombinase in myeloid cells). These mice were then crossed with LDLR knockout mice (The Jackson Laboratory, Bar Harbor, ME).
  2. Additional Name
    LysM-Cre COX-2 KO / LDLR KO
  3. Contact
    Teegarden, Sarah., PhD
  4. Related Disease
    cardiovascular system disease
  5. Related Publication or Documentation
    Targeted Deletions of Cyclooxygenase-2 and Atherogenesis in Mice
  6. Genetic Alteration(s)
    Floxed COX-2
  7. Genetic Alteration(s)
    LDLR Knockout
  8. Genetic Alteration(s)
  9. Phenotype Findings
    Reduced atherogenesis
  10. Location
    FitzGerald Lab
Provenance Metadata About This Resource Record
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016