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Villin-Cdx2 mice

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013a-f51b-a365-e44e-976d80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    These transgenic mice overexpress Cdx2 in the small intestinal and colonic epithelium. Transgene expression was first detected by embryonic day 15.5. Adult transgene expression pattern is mosaic. Phenotypes are linked to levels of transgene expression.
  2. Related Disease
    gastrointestinal system disease
  3. Related Publication or Documentation
    Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development
  4. Related Technique
    Microinjection
  5. Biological process studied
    Cell differentiation
  6. Genetic Alteration(s)
    Villin-(FLAG)-Cdx2 insertion
  7. Transgenic Construct
    pCMV-Tag3c-Villin-(FLAG)-Cdx2
  8. Phenotype Findings
    Fat malabsorption
  9. Phenotype Findings
    Premature maturation of the intestinal epithelium
  10. Phenotype Findings
    Altered crypt organization
  11. Location
    John Lynch Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow owner
    fcoldren
  2. workflow state
    Published
  3. contributor
    fcoldren
  4. created
    2012-11-12T09:54:10.555-05:00
  5. creator
    fcoldren
  6. modified
    2012-11-19T16:01:29.007-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016