Villin-Cdx2 mice

eagle-i ID

Resource Type

Properties

1. Resource Description

   These transgenic mice overexpress Cdx2 in the small intestinal and colonic epithelium. Transgene expression was first detected by embryonic day 15.5. Adult transgene expression pattern is mosaic. Phenotypes are linked to levels of transgene expression.

2. Related Disease

   gastrointestinal system disease

3. Related Publication or Documentation

   Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development

4. Related Technique

   Microinjection

5. Biological process studied

   Cell differentiation

6. Genetic Alteration(s)

   Villin-(FLAG)-Cdx2 insertion

7. Transgenic Construct

   pCMV-Tag3c-Villin-(FLAG)-Cdx2

8. Phenotype Findings

   Fat malabsorption

9. Phenotype Findings

   Premature maturation of the intestinal epithelium

10. Phenotype Findings

    Altered crypt organization

11. Location

    John Lynch Laboratory