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COX-1 Knocked In To COX-2 Locus
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013a-fa78-edd5-e44e-976d80000000
Resource Type
Mus musculus
Properties
Resource Description
COX-1 > COX-2 mice were generated by replacing most of the coding region of Ptgs2 (exons 1-9) with Ptgs1 cDNA while leaving the Ptgs2 promoter region and 3’-UTR intact through conventional gene targeting technology.
Additional Name
COX-1>COX-2 mouse
Contact
Teegarden, Sarah., PhD
Related Disease
D020763
Related Disease
cardiovascular system disease
Related Disease
female reproductive system disease
Related Disease
gastrointestinal system disease
Related Publication or Documentation
Cyclooxygenase-2-Dependent Prostacyclin Formation and Blood Pressure Homeostasis: Targeted Exchange of Cyclooxygenase Isoforms in Mice
Related Publication or Documentation
Targeted Cyclooxygenase Gene (Ptgs) Exchange Reveals Discriminant Isoform Functionality
Genetic Alteration(s)
COX-1 Knockin
Genetic Alteration(s)
COX-2 Knockout
Phenotype Findings
Reproductive phenotype
Phenotype Findings
Renal development
Phenotype Findings
Peritonitis
Phenotype Findings
Hypertension
Location
FitzGerald Lab
Inferred Types from the eagle-i Ontology (
What is an ontology?
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entity
continuant
independent_continuant
material_entity
Organism
Mus <mouse, genus>
Glires
Mammalia
Chordata
Vertebrata <Metazoa>
Rodentia
Organism or Virus
Thing
Provenance Metadata About This Resource Record
workflow state
Published
contributor
tjohnson (Tenille Johnson)
created
2012-11-13T10:56:10.936-05:00
creator
sarahtee (Sarah Teegarden)
modified
2016-09-02T10:15:22.567-04:00