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COX-1 Knocked In To COX-2 Locus

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013a-fa78-edd5-e44e-976d80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    COX-1 > COX-2 mice were generated by replacing most of the coding region of Ptgs2 (exons 1-9) with Ptgs1 cDNA while leaving the Ptgs2 promoter region and 3’-UTR intact through conventional gene targeting technology.
  2. Additional Name
    COX-1>COX-2 mouse
  3. Contact
    Teegarden, Sarah, Ph.D.
  4. Related Disease
    D020763
  5. Related Disease
    cardiovascular system disease
  6. Related Disease
    female reproductive system disease
  7. Related Disease
    gastrointestinal system disease
  8. Related Publication or Documentation
    Cyclooxygenase-2-Dependent Prostacyclin Formation and Blood Pressure Homeostasis: Targeted Exchange of Cyclooxygenase Isoforms in Mice
  9. Related Publication or Documentation
    Targeted Cyclooxygenase Gene (Ptgs) Exchange Reveals Discriminant Isoform Functionality
  10. Genetic Alteration(s)
    COX-1 Knockin
  11. Genetic Alteration(s)
    COX-2 Knockout
  12. Phenotype Findings
    Reproductive phenotype
  13. Phenotype Findings
    Renal development
  14. Phenotype Findings
    Peritonitis
  15. Phenotype Findings
    Hypertension
  16. Location
    FitzGerald Lab
 
RDFRDF
 
Provenance Metadata About This Resource Record

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016