COX-1 Knocked In To COX-2 Locus

eagle-i ID

Resource Type

Properties

1. Resource Description

   COX-1 > COX-2 mice were generated by replacing most of the coding region of Ptgs2 (exons 1-9) with Ptgs1 cDNA while leaving the Ptgs2 promoter region and 3’-UTR intact through conventional gene targeting technology.

2. Additional Name

   COX-1>COX-2 mouse

3. Contact

   Teegarden, Sarah, Ph.D.

4. Related Disease

   D020763

5. Related Disease

   cardiovascular system disease

6. Related Disease

   female reproductive system disease

7. Related Disease

   gastrointestinal system disease

8. Related Publication or Documentation

   Cyclooxygenase-2-Dependent Prostacyclin Formation and Blood Pressure Homeostasis: Targeted Exchange of Cyclooxygenase Isoforms in Mice

9. Related Publication or Documentation

   Targeted Cyclooxygenase Gene (Ptgs) Exchange Reveals Discriminant Isoform Functionality

10. Genetic Alteration(s)

    COX-1 Knockin

11. Genetic Alteration(s)

    COX-2 Knockout

12. Phenotype Findings

    Reproductive phenotype

13. Phenotype Findings

    Renal development

14. Phenotype Findings

    Peritonitis

15. Phenotype Findings

    Hypertension

16. Location

    FitzGerald Lab