eagle-i The University of PennsylvaniaThe University of Pennsylvania
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Inducible Cardiomyocyte COX-2 Knockout

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013b-4de2-a75f-83a0-df0880000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Exons 6, 7, 8 and of COX-2 (PTGS2) were flanked by two directly repeated loxp sites inserted into the corresponding introns. These mice were then crossed into merCremer mice under the alpha-myosin heavy chain promoter to permit tamoxifen-dependent deletion of COX-2 in cardiomyocytes.
  2. Contact
    Teegarden, Sarah, Ph.D.
  3. Related Publication or Documentation
    Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function
  4. Genetic Alteration(s)
    Floxed COX-2
  5. Genetic Alteration(s)
    Tg(Myh6-cre/Esr1*)1Jmk
  6. Phenotype Findings
    Decreased cardiac output
  7. Phenotype Findings
    Decreased exercise tolerance
  8. Phenotype Findings
    Enhanced susceptibility to induced arrythmogenesis
  9. Location
    FitzGerald Lab
 
RDFRDF
 
Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016