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Inducible Cardiomyocyte COX-2 Knockout

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    Exons 6, 7, 8 and of COX-2 (PTGS2) were flanked by two directly repeated loxp sites inserted into the corresponding introns. These mice were then crossed into merCremer mice under the alpha-myosin heavy chain promoter to permit tamoxifen-dependent deletion of COX-2 in cardiomyocytes.
  2. Contact
    Teegarden, Sarah., PhD
  3. Related Publication or Documentation
    Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function
  4. Genetic Alteration(s)
    Floxed COX-2
  5. Genetic Alteration(s)
  6. Phenotype Findings
    Decreased cardiac output
  7. Phenotype Findings
    Decreased exercise tolerance
  8. Phenotype Findings
    Enhanced susceptibility to induced arrythmogenesis
  9. Location
    FitzGerald Lab
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016