eagle-i The University of PennsylvaniaThe University of Pennsylvania
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.


eagle-i ID


Resource Type

  1. Database


  1. Related Software
  2. Resource Description
    "Circadian rhythms drive daily oscillations in many different physiologies, including blood pressure, body temperature and behavior. In addition, disruptions of the circadian clock contribute to the pathologies of metabolic disorders as well as cardiovascular disease and cancer. Our lab is interested in the mechanism by which circadian oscillations drive these processes. We are using microarray analysis in combination with curve-fitting and Fourier-transform based statistical algorithms to search the genome for transcripts which oscillate under circadian control. We have identified more than 3000 cycling genes in the liver and smaller subsets of rhythmic genes in the pituitary and fibroblasts. We are currently expanding our initial studies to identify rhythmic transcripts in over 15 different tissue types including the heart, kidneys and brain. These data sets will be mined using bioinformatic techniques to discover novel circadian regulatory elements, characterize components of the circadian clock, and identify regulatory genes responsible for the physiologies and pathologies associated with circadian rhythms."
  3. Used by
    Hogenesch Laboratory
  4. Data Input
    Microarray data
  5. Topic
    circadian rhythm
  6. Related Publication or Documentation
    CircaDB: a database of mammalian circadian gene expression profiles
  7. Related Publication or Documentation
    A circadian gene expression atlas in mammals: Implications for biology and medicine
  8. Website(s)
  9. Website(s)
  10. Related Technique
    Transcription profiling
  11. Developed by
    Hogenesch, John B., PhD
  12. Developed by
    Hayer, Katharina
  13. Developed by
    Lahens, Nicholas F., PhD
  14. Coded in
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
    ggrant (Gregory Grant)
  3. created
  4. creator
  5. modified
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016