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COX-2 Y385F

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013b-52bb-28be-83a0-df0880000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    We introduced a point mutation (1121a→t) into the Ptgs2 gene (which encodes PGHS2) of mice by gene targeting, resulting in a Y385F substitution, to create a genetic mimic of selective COX-2 inhibition (cycloxygenase activity is inhibited, but peroxidase activity is intact). We numbered the tyrosine residue of PGHS2 in accordance with the numbering of sheep PGHS1, the recognized standard for numbering amino acid residues of PHGS isoforms. Accordingly, the actual position of the affected tyrosine residue in mouse PGHS2 is Tyr371 based on numbering the amino-terminal methionine of the signal peptide as residue 1.
  2. Contact
    Teegarden, Sarah, Ph.D.
  3. Related Disease
    D009358
  4. Related Disease
    D020763
  5. Related Disease
    cardiovascular system disease
  6. Related Disease
    female reproductive system disease
  7. Related Disease
    placenta disease
  8. Related Publication or Documentation
    Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
  9. Related Publication or Documentation
    Genetic model of selective COX2 inhibition reveals novel heterodimer signaling
  10. Genetic Alteration(s)
    COX-2 Y385F
  11. Phenotype Findings
    Closure of ductus arteriosus
  12. Phenotype Findings
    Abnormal renal development
  13. Phenotype Findings
    Reproductive phenotype
  14. Phenotype Findings
    Cardiovascular phenotype
  15. Location
    FitzGerald Lab
 
RDFRDF
 
Provenance Metadata About This Resource Record

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016