eagle-i The University of PennsylvaniaThe University of Pennsylvania
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

COX-2 Y385F

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    We introduced a point mutation (1121a→t) into the Ptgs2 gene (which encodes PGHS2) of mice by gene targeting, resulting in a Y385F substitution, to create a genetic mimic of selective COX-2 inhibition (cycloxygenase activity is inhibited, but peroxidase activity is intact). We numbered the tyrosine residue of PGHS2 in accordance with the numbering of sheep PGHS1, the recognized standard for numbering amino acid residues of PHGS isoforms. Accordingly, the actual position of the affected tyrosine residue in mouse PGHS2 is Tyr371 based on numbering the amino-terminal methionine of the signal peptide as residue 1.
  2. Contact
    Teegarden, Sarah., PhD
  3. Related Disease
  4. Related Disease
  5. Related Disease
    cardiovascular system disease
  6. Related Disease
    female reproductive system disease
  7. Related Disease
    placenta disease
  8. Related Publication or Documentation
    Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
  9. Related Publication or Documentation
    Genetic model of selective COX2 inhibition reveals novel heterodimer signaling
  10. Genetic Alteration(s)
    COX-2 Y385F
  11. Phenotype Findings
    Closure of ductus arteriosus
  12. Phenotype Findings
    Abnormal renal development
  13. Phenotype Findings
    Reproductive phenotype
  14. Phenotype Findings
    Cardiovascular phenotype
  15. Location
    FitzGerald Lab
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016