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COX-2 Y385F
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013b-52bb-28be-83a0-df0880000000
Resource Type
Properties
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Resource Description
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We introduced a point mutation (1121a→t) into the Ptgs2 gene (which encodes PGHS2) of mice by gene targeting, resulting in a Y385F substitution, to create a genetic mimic of selective COX-2 inhibition (cycloxygenase activity is inhibited, but peroxidase activity is intact). We numbered the tyrosine residue of PGHS2 in accordance with the numbering of sheep PGHS1, the recognized standard for numbering amino acid residues of PHGS isoforms. Accordingly, the actual position of the affected tyrosine residue in mouse PGHS2 is Tyr371 based on numbering the amino-terminal methionine of the signal peptide as residue 1.
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Contact
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Teegarden, Sarah., PhD
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Related Disease
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D009358
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Related Disease
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D020763
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Related Disease
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cardiovascular system disease
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Related Disease
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female reproductive system disease
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Related Disease
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placenta disease
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Related Publication or Documentation
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Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
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Related Publication or Documentation
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Genetic model of selective COX2 inhibition reveals novel heterodimer signaling
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Genetic Alteration(s)
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COX-2 Y385F
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Phenotype Findings
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Closure of ductus arteriosus
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Phenotype Findings
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Abnormal renal development
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Phenotype Findings
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Reproductive phenotype
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Phenotype Findings
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Cardiovascular phenotype
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Location
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FitzGerald Lab
