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Stem Cell & Xenograft Core (Penn)

eagle-i ID


Resource Type

  1. Core Laboratory


  1. Resource Description
    The Stem Cell and Xenograft Core (SCXC) is a comprehensive resource laboratory that integrates a viable tissue bank of normal human hematopoietic cells and hematopoietic malignancies with a full range of xenograft services. The SCXC is committed to facilitating and promoting translational research involving viable primary human hematopoietic tissues. Our core offers adult whole bone marrow from healthy donors and umbilical cord blood. Mononuclear and CD34+ cells from normal bone marrow and cord blood are available, and other cell fractions can be provided by arrangement. We maintain a large tissue bank of cells from hematopoietic malignancies including AML, ALL, CML, MDS and MPDs. All samples are fully annotated and frozen as viable cells. We also offer access to an immunomagnetic cell sorter (Miltneyi AutoMacs). Expertise in primary human hematopoietic stem/progenitor and leukemic cell culture and manipulation is available. For consultation or questions, please contact Martin Carroll. The SCXC offers a wide variety of xenograft services from training to full-service experiments. The Core maintains a large breeding colony of immune-deficient (NSG) mice for users xenograft studies. We also offer human immune system (CD34-transplanted) NSG mice for a wide variety of studies ranging from gene therapy to HIV. Experimental animals are housed in dedicated BSL-2 animal barrier space equipped for whole body irradiation and all necessary procedures and survival surgeries. Currently established xenograft models include normal human CD34 and leukemia engraftment, human iPS and ES-derived teratomas, human skin grafting, orthotopic human ovarian, hepatic and pancreatic tumor cell injections, renal capsule implantation. We also offer access to a dedicated optical/fluorescence (IVIS Spectrum) imaging system located within the Core's BSL-2 space. For consultation or questions, please contact Gwenn Danet-Desnoyers. Pennkey required to request services, contact to acquire a guest Pennkey if needed.
  2. Contact
    Danet-Desnoyers, Gwenn., PhD
  3. Affiliation
    Perelman School of Medicine
  4. Affiliation
    Biomedical Research Core Facilities
  5. Performs Technique
    Mouse breeding
  6. Performs Technique
    Blood sampling
  7. Performs Technique
    Biological sample processing
  8. Performs Technique
    Rodent irradiation
  9. Performs Technique
    Animal handling
  10. Performs Technique
    Clinical assay
  11. Performs Technique
    Imaging technique
  12. Performs Technique
    Cell storage
  13. Performs Technique
    Bone marrow aspiration
  14. Performs Technique
    Isolation of cell population
  15. Website(s)
  16. Website(s)
  17. Director
    Danet-Desnoyers, Gwenn., PhD
  18. Director
    Carroll, Martin., MD
  19. Director
    Shan, Xiaochuan., MD, PhD
  20. Secondary affiliation
    Abramson Cancer Center
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
    ggrant (Gregory Grant)
  3. created
  4. creator
    bjc2 (Joy Cannon)
  5. modified
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016