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Epstein Laboratory

eagle-i ID


Resource Type

  1. Laboratory


  1. Resource Description
    "The Epstein Laboratory studies cardiovascular development, the genetics of congenital heart disease and cardiovascular regenerative and stem cell biology. The lab has a long-standing interest in congenital heart defects involving the outflow tract of the heart, the role of neural crest, the epicardium and the second heart field. More recent areas of focus include the cardiac inflow tract and the pulmonary veins and the origin of anomalous pulmonary venous return. Other areas of interest include the factors and genes involved in progressive lineage restriction of cardiac progenitor cells and the role of epigenetics in progenitor cell expansion and differentiation. The lab is also interested in the implications of these studies for the development of new therapies for adult cardiovascular disorders including heart failure and arrhythmia. Specific projects have focused on the role of Notch and Wnt in cardiac progenitors, semaphorin signaling in the developing vasculature, the function of a novel homeobox gene Hopx and histone deacetylases in stem cells and the heart, and the role of the type I Neurofibromatosis gene (Nf1) in mouse and zebrafish cardiac development."
  2. PI
    Epstein, Jonathan A., MD
  3. Affiliation
    Department of Cell and Developmental Biology, University of Pennsylvania
  4. Affiliation
    Department of Medicine, University of Pennsylvania
  5. Website(s)
  6. Secondary affiliation
    Penn Cardiovascular Institute
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
    ggrant (Gregory Grant)
  3. created
  4. creator
  5. modified
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016