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Zebrafish model of NF1

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-2558-2896-f162-a2b280000000

Resource Type

  1. Danio rerio

Properties

  1. Resource Description
    After identifying and characterizing the zebrafish orthologues (nf1a and nf1b) of the human neurofibromatosis gene NF1, morpholino antisense oligonucleotides were used to inhibit expression of these orthologues in zebrafish embryos in which endothelial cells were marked by expression of cytoplasmic enhanced green fluorescent protein. Cardiovascular and vascular patterning defects were greater with knockdown of nf1a than nf1b, suggesting that nf1a may play a more prominent role in cardiovascular development.
  2. Related Disease
    neurofibromatosis
  3. Related Publication or Documentation
    Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI
  4. Phenotype Findings
    Cardiovascular defects
  5. Phenotype Findings
    Vascular patterning defects
  6. Phenotype Findings
    Abnormal vascular shunting with concurrent flt4 knockdown
  7. Location
    Epstein Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-01-10T12:04:14.023-05:00
  4. creator
    fcoldren
  5. modified
    2013-01-10T17:07:36.683-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016