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B6.129P2-Akt1 tm1Mbb/J

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    "Mice that are homozygous for the targeted mutation are viable and do not display any gross behavioral abnormalities. Homozygotes exhibit lower fertility. Female homozygotes do not nurse well; up to 50% perinatal mortality can occur. No gene product (mRNA or protein) is detected by Northern or Western blot analysis of mouse embryonic fibroblasts. Homozygotes are only 80% of wildtype body weight at birth, and remain small. This mutant mouse strain may be useful in related to organismal growth."
  2. Additional Name
  3. Related Disease
  4. Related Publication or Documentation
    Loss of Akt1 in Mice Increases Energy Expenditure and Protects against Diet-Induced Obesity
  5. Related Publication or Documentation
    Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
  6. Website(s)
  7. Parental Strain Name
  8. Genetic Alteration(s)
    Akt1 KO
  9. Phenotype Findings
    Improved insulin sensitivity
  10. Phenotype Findings
    Protection from diet-induced obesity
  11. Phenotype Findings
    Decreased size
  12. Phenotype Findings
    Elevated energy expenditure
  13. Phenotype Findings
    Energy metabolism in skeletal muscle
  14. Location
    Birnbaum Laboratory
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016