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Nf1 flox/- ;Tie2-Cre mice

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-2a17-849b-f162-a2b280000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    The Nf1<sup>flox/-</sup>;Tie2-Cre mice were produced from two crosses: <b>Cross 1:</b> Nf1<sup>+/-</sup> X Tie2-Cre <b>Cross 2:</b> Cross 1 X Nf1<sup>flox/flox</sup> Tie2-Cre mice express Cre in endothelial cells and in the hematopoietic lineage. Tie2-Cre efficiently recombined the floxed NF1 allele in most hematopoietic cells. Before 3 months of age mice appeared healthy and active. Some offspring from the cross to generate Nf1<sup>flox/-</sup>;Tie2-Cre mice died at mid-gestation of heart defects.
  2. Related Disease
    juvenile myelomonocytic leukemia
  3. Related Disease
    bone marrow cancer
  4. Related Publication or Documentation
    Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia
  5. Parental Strain Name
    Nf1<sup>+/-</sup>
  6. Parental Strain Name
    Nf1<sup>flox/flox</sup>
  7. Parental Strain Name
    Tie2-Cre
  8. Genetic Alteration(s)
    Tie2-Cre
  9. Genetic Alteration(s)
    Nf1 targeted mutation
  10. Phenotype Findings
    Myeloproliferative phenotype
  11. Phenotype Findings
    Splenomegaly
  12. Phenotype Findings
    Expansion of red pulp
  13. Phenotype Findings
    Abnormal bone marrow phenotype
  14. Location
    Epstein Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-01-11T10:10:28.489-05:00
  4. creator
    fcoldren
  5. modified
    2013-01-11T13:50:23.965-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016