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eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    Transgenic lines were obtained by pronuclear injection into fertilized C57BL/6;SJLF1 hybrid oocytes. This line displays efficient deletion of <i>Foxa2</i> in the liver.
  2. Related Publication or Documentation
    Foxa2 integrates the transcriptional response of the hepatocyte to fasting
  3. Biological process studied
    Metabolic process
  4. Genetic Alteration(s)
    Floxed Foxa2
  5. Genetic Alteration(s)
    AlfpCre insertion
  6. Transgenic Construct
    Construct for hepatocyte-specific expression of Cre in mice
  7. Phenotype Findings
    Blunting of hepatic transcriptional response to fasting
  8. Phenotype Findings
    Reduced binding of glucocorticoid receptor to targets
  9. Phenotype Findings
    Upregulation of Foxa1
  10. Location
    Kaestner Laboratory
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016