eagle-i The University of PennsylvaniaThe University of Pennsylvania
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Foxa2<sup>loxP/loxP</sup>;AlfpCre

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-72e9-4498-f162-a2b280000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Transgenic lines were obtained by pronuclear injection into fertilized C57BL/6;SJLF1 hybrid oocytes. This line displays efficient deletion of <i>Foxa2</i> in the liver.
  2. Related Publication or Documentation
    Foxa2 integrates the transcriptional response of the hepatocyte to fasting
  3. Biological process studied
    Metabolic process
  4. Genetic Alteration(s)
    Floxed Foxa2
  5. Genetic Alteration(s)
    AlfpCre insertion
  6. Transgenic Construct
    Construct for hepatocyte-specific expression of Cre in mice
  7. Phenotype Findings
    Blunting of hepatic transcriptional response to fasting
  8. Phenotype Findings
    Reduced binding of glucocorticoid receptor to targets
  9. Phenotype Findings
    Upregulation of Foxa1
  10. Location
    Kaestner Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-01-25T13:15:29.659-05:00
  4. creator
    fcoldren
  5. modified
    2013-02-08T16:44:59.111-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016