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Liver-specific knockout of Akt1, Akt2, and Foxo1

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    Akt1<sup>loxP/loxP</sup>;Akt2<sup>loxP/loxP</sup> mice were crossed with Foxo1<sup>loxP/loxP</sup> mice. The liver-specific Akt1;Akt2;Foxo1 knockout mice were created by injecting Akt1<sup>loxP/loxP</sup>;Akt2 <sup>loxP/loxP</sup>;Foxo1<sup>loxP/loxP</sup> mice with adeno-associated virus expressing Cre recombinase under the control of the Tbg promoter (AAV-Tbg-Cre).
  2. Additional Name
  3. Related Disease
    diabetes mellitus
  4. Related Publication or Documentation
    Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
  5. Parental Strain Name
    129–C57BL–6J/FVB mixed
  6. Genetic Alteration(s)
  7. Genetic Alteration(s)
    Floxed Akt1
  8. Genetic Alteration(s)
    Floxed Foxo1
  9. Phenotype Findings
    Normalized hyperglycemia, glucose intolerance, and hyperinsulinemia despite defective insulin signaling
  10. Phenotype Findings
    Normal nutritional regulation of hepatic gene expression
  11. Location
    Birnbaum Laboratory
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