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Liver-specific Foxa1;Foxa2 knockout

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    The expression of Cre recombinase in AlfpCre mice is driven by the Alb promoter and both Alb and Afp enhancers. Both Afp and Alb are initially expressed in the hepatoblast at E9.0. Ablation of <i>Foxa1/2</i> was first apparent in the liver at E16.5, complete by P2, and maintained into adulthood.
  2. Additional Name
    Foxa1<sup>loxP/loxP</sup>; Foxa2<sup>loxP/loxP</sup>; AlfpCre
  3. Related Disease
    hepatocellular carcinoma
  4. Related Disease
    biliary tract disease
  5. Related Publication or Documentation
    Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer
  6. Related Publication or Documentation
    Foxa1 and Foxa2 regulate bile duct development in mice
  7. Parental Strain Name
  8. Genetic Alteration(s)
    Floxed Foxa2
  9. Genetic Alteration(s)
    AlfpCre insertion
  10. Genetic Alteration(s)
    Floxed Foxa1
  11. Phenotype Findings
    Bile duct hyperplasia
  12. Phenotype Findings
    Increased cholangiocytes proliferation rate
  13. Phenotype Findings
  14. Phenotype Findings
    Plasma IL-6 levels were dramatically elevated
  15. Phenotype Findings
    Induced hepatocellular carcinoma more prevalent and severe in females
  16. Phenotype Findings
    Increased Foxa1, Foxa2, and AR binding sites in males after carcinogen exposure
  17. Phenotype Findings
    Estrogen enhanced liver injury in males and attenuated injury in females
  18. Location
    Kaestner Laboratory
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016