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Pancreatic beta cell-specific Foxa2 knockout

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-878d-59cb-f162-a2b280000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    These mice were generated by breeding <i>Foxa2<sup>loxP/loxP</sup></i> homozygous mice with Ins.Cre transgenic mice, which express the Cre recombinase cDNA under the control of the beta cell-specific rat insulin 2 promoter. The resulting <i>Foxa2<sup>loxP/+</sup></i>; Ins.Cre offspring were mated to <i>Foxa2<sup>loxP/loxP</sup></i> homozygotes to obtain the <i>Foxa2<sup>loxP/loxP</sup></i>; Ins.Cre mice.
  2. Additional Name
    <i>Foxa2<sup>loxP/loxP</sup></i>;Ins.Cre
  3. Related Disease
    hyperinsulinism
  4. Related Disease
    hypoglycemia
  5. Related Publication or Documentation
    Tissue-specific deletion of Foxa2 in pancreatic β cells results in hyperinsulinemic hypoglycemia
  6. Parental Strain Name
    mixed outbred-CD1
  7. Genetic Alteration(s)
    Floxed Foxa2
  8. Genetic Alteration(s)
    Insulin-Cre
  9. Phenotype Findings
    Normal birth weight and appearance
  10. Phenotype Findings
    Retarded postnatal weight gain
  11. Phenotype Findings
    Complete preweaning lethality
  12. Phenotype Findings
    Metabolic dysfunction
  13. Phenotype Findings
    Irregular islet architecture
  14. Phenotype Findings
    Defective regulation of hormone secretion
  15. Location
    Kaestner Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-01-29T13:24:48.867-05:00
  4. creator
    fcoldren
  5. modified
    2013-02-08T16:18:09.695-05:00

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