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Pancreatic beta cell-specific Foxa2 knockout

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    These mice were generated by breeding <i>Foxa2<sup>loxP/loxP</sup></i> homozygous mice with Ins.Cre transgenic mice, which express the Cre recombinase cDNA under the control of the beta cell-specific rat insulin 2 promoter. The resulting <i>Foxa2<sup>loxP/+</sup></i>; Ins.Cre offspring were mated to <i>Foxa2<sup>loxP/loxP</sup></i> homozygotes to obtain the <i>Foxa2<sup>loxP/loxP</sup></i>; Ins.Cre mice.
  2. Additional Name
  3. Related Disease
  4. Related Disease
  5. Related Publication or Documentation
    Tissue-specific deletion of Foxa2 in pancreatic β cells results in hyperinsulinemic hypoglycemia
  6. Parental Strain Name
    mixed outbred-CD1
  7. Genetic Alteration(s)
    Floxed Foxa2
  8. Genetic Alteration(s)
  9. Phenotype Findings
    Normal birth weight and appearance
  10. Phenotype Findings
    Retarded postnatal weight gain
  11. Phenotype Findings
    Complete preweaning lethality
  12. Phenotype Findings
    Metabolic dysfunction
  13. Phenotype Findings
    Irregular islet architecture
  14. Phenotype Findings
    Defective regulation of hormone secretion
  15. Location
    Kaestner Laboratory
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016