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Intestine-specific Foxa1;Foxa2 knockout

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-8795-a1a0-f162-a2b280000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    A series of crosses was used to produce mice with intestine-specific deletion of <i>Foxa1</i> and <i>Foxa2</i>. Foxa1 and Foxa2 proteins were absent from the small intestine, colon, and rectum.
  2. Additional Name
    Foxa1/a2 mutant
  3. Additional Name
    Foxa1<sup>loxP/loxP</sup>;Foxa2<sup>loxP/loxP</sup>;Villin-Cre
  4. Related Disease
    colitis
  5. Related Disease
    intestinal disease
  6. Related Publication or Documentation
    Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-Cells in mice
  7. Biological process studied
    Cell differentiation
  8. Genetic Alteration(s)
    Floxed Foxa2
  9. Genetic Alteration(s)
    Villin-Cre
  10. Genetic Alteration(s)
    Floxed Foxa1
  11. Phenotype Findings
    Reduced body weight and slower growth rate
  12. Phenotype Findings
    Defective goblet cell differentiation
  13. Phenotype Findings
    Decreased enteroendocrine cell differentiation
  14. Phenotype Findings
    Decreased differentiation of L- and D-cells
  15. Location
    Kaestner Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-01-29T13:34:41.964-05:00
  4. creator
    fcoldren
  5. modified
    2013-02-08T16:57:15.309-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016