eagle-i The University of PennsylvaniaThe University of Pennsylvania

Defective goblet cell differentiation

eagle-i ID


Resource Type

  1. Mammal-specific phenotype


  1. Resource Description
    Mice displayed a significant decrease of goblet cell numbers in the duodenum, jejunum and ileum compared to controls. In both colon and rectum, partially or completely empty vacuoles were observed in goblet cells. Overall granule density was reduced, indicating fewer mucins contained within each granule compared to controls. The mucin expression profile was dramatically altered.
  2. Mammalian phenotype
    abnormal intestinal goblet cell morphology
Provenance Metadata About This Resource Record
    Copyright © 2016 by the President and Fellows of Harvard College
    The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016