eagle-i The University of PennsylvaniaThe University of Pennsylvania

Decreased differentiation of L- and D-cells

eagle-i ID


Resource Type

  1. Mammal-specific phenotype


  1. Resource Description
    Glp-1 and Glp-2 positive cells were absent from the small intestine. Fewer somatostatin and PYY positive cells were observed compared to control mice. Compared with control mice, somatostatin mRNA levels were reduced by 71% and 83% in the duodenum and jejunum, respectively. PYY expression is restricted to the ileum and was significantly decreased (80%) compared to controls.
  2. Mammalian phenotype
    abnormal intestinal enteroendocrine cell morphology
Provenance Metadata About This Resource Record
    Copyright © 2016 by the President and Fellows of Harvard College
    The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016