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eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    <i>Cdx2</i> null mice die before gastrulation. <i>Cdx2<sup>loxP/loxP</sup></i>, however, are viable and fertile with a fuctionally wild type <i>Cdx2<sup>loxP</sup></i> allele. A conditional <i>Cdx2</i> allele was derived by targeting embryonic stem cells. After germ line transmission of the targeted allele, the FRT-flanked neomycin resistance gene was removed by crossing to <i>Flp1</i> deleter mice. <i>Cdx2<sup>loxP/loxP</sup></i> were derived by intercrossing <i>Cdx2<sup>loxP/+</sup></i> mice. These mice can be used to develop conditional <i>Cdx2</i> knockouts.
  2. Related Disease
    intestinal disease
  3. Related Publication or Documentation
    Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
  4. Related Publication or Documentation
    Cdx2 regulates endo-lysosomal function and epithelial cell polarity
  5. Biological process studied
    Developmental process
  6. Genetic Alteration(s)
    Floxed Cdx2
  7. Phenotype Findings
    Viable and fertile mice
  8. Location
    Kaestner Laboratory
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016