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Cdx2(loxP/loxP)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-bb0d-7b5b-f162-a2b280000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    <i>Cdx2</i> null mice die before gastrulation. <i>Cdx2<sup>loxP/loxP</sup></i>, however, are viable and fertile with a fuctionally wild type <i>Cdx2<sup>loxP</sup></i> allele. A conditional <i>Cdx2</i> allele was derived by targeting embryonic stem cells. After germ line transmission of the targeted allele, the FRT-flanked neomycin resistance gene was removed by crossing to <i>Flp1</i> deleter mice. <i>Cdx2<sup>loxP/loxP</sup></i> were derived by intercrossing <i>Cdx2<sup>loxP/+</sup></i> mice. These mice can be used to develop conditional <i>Cdx2</i> knockouts.
  2. Related Disease
    intestinal disease
  3. Related Publication or Documentation
    Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
  4. Related Publication or Documentation
    Cdx2 regulates endo-lysosomal function and epithelial cell polarity
  5. Biological process studied
    Developmental process
  6. Genetic Alteration(s)
    Floxed Cdx2
  7. Phenotype Findings
    Viable and fertile mice
  8. Location
    Kaestner Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-02-08T13:29:50.174-05:00
  4. creator
    fcoldren
  5. modified
    2013-02-08T16:39:47.864-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016