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Foxa3/Cdx2 transgenic mice

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-bb29-520f-f162-a2b280000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    A transgenic founder with integration of the full <i>Foxa3/Cdx2</i> YAC was derived from <i>Foxa3/Cdx2</i> YAC-injected oocytes. Cdx2 is expressed early in fetal development and continues to be expressed in the gastric mucosa throughout development and adulthood. These mice express Cdx2 protein throughout the epithelium of the glandular gastric mucosa. The ectopic expression of Cdx2 in the gastric epithelium is sufficient to cause transdifferentiation of the gastric mucosa to an intestinal cell-type characteristic of human intestinal metaplasia.
  2. Related Disease
    pre-malignant neoplasm
  3. Related Publication or Documentation
    Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice
  4. Genetic Alteration(s)
    Foxa3/Cdx2
  5. Phenotype Findings
    Small stomach size
  6. Phenotype Findings
    Intestinal metaplasia
  7. Location
    Kaestner Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-02-08T14:00:28.657-05:00
  4. creator
    fcoldren
  5. modified
    2013-02-08T16:37:28.204-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016