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Foxa3/Cdx2 transgenic mice

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    A transgenic founder with integration of the full <i>Foxa3/Cdx2</i> YAC was derived from <i>Foxa3/Cdx2</i> YAC-injected oocytes. Cdx2 is expressed early in fetal development and continues to be expressed in the gastric mucosa throughout development and adulthood. These mice express Cdx2 protein throughout the epithelium of the glandular gastric mucosa. The ectopic expression of Cdx2 in the gastric epithelium is sufficient to cause transdifferentiation of the gastric mucosa to an intestinal cell-type characteristic of human intestinal metaplasia.
  2. Related Disease
    pre-malignant neoplasm
  3. Related Publication or Documentation
    Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice
  4. Genetic Alteration(s)
  5. Phenotype Findings
    Small stomach size
  6. Phenotype Findings
    Intestinal metaplasia
  7. Location
    Kaestner Laboratory
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016