Crk(loxP/loxP); Nestin-Cre

eagle-i ID

Resource Type

Properties

1. Resource Description

   Nestin-Cre transgenic mice from Jackson laboratory were bred with floxed <i>Crk</i> mice.

2. Additional Name

   Neuron-specific <i>Crk</i> knockout

3. Related Publication or Documentation

   Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway

4. Parental Strain Name

   C57BL/6 x 129SvEv

5. Biological process studied

   Brain development

6. Genetic Alteration(s)

   Floxed Crk

7. Genetic Alteration(s)

   Nestin-Cre

8. Phenotype Findings

   Reduced body weight

9. Phenotype Findings

   Normal brain morphology

10. Location

    Curran Laboratory