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eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    129/SvEv mouse ES cells were electroporated with a linearized targeting construct that contained the first exon of <i>CrkL</i>, flanked by two loxP sites, followed by a <i>NeoTK</i> gene and another loxP site. C57BL/6 × 129 chimeras were obtained. This line can be used to generate tissue-specific <i>CrkL</i> knockouts.
  2. Related Publication or Documentation
    Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway
  3. Related Publication or Documentation
    Cardiovascular and craniofacial defects in Crk-null mice
  4. Parental Strain Name
    C57BL/6 x 129
  5. Genetic Alteration(s)
    Floxed CrkL
  6. Location
    Curran Laboratory
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016