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CrkL(loxP/loxP)
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013c-c9c5-f423-f162-a2b280000000
Resource Type
Properties
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Resource Description
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129/SvEv mouse ES cells were electroporated with a linearized targeting construct that contained the first exon of <i>CrkL</i>, flanked by two loxP sites, followed by a <i>NeoTK</i> gene and another loxP site. C57BL/6 × 129 chimeras were obtained.
This line can be used to generate tissue-specific <i>CrkL</i> knockouts.
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Related Publication or Documentation
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Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway
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Related Publication or Documentation
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Cardiovascular and craniofacial defects in Crk-null mice
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Parental Strain Name
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C57BL/6 x 129
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Genetic Alteration(s)
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Floxed CrkL
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Location
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Curran Laboratory
The University of Pennsylvania
