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CrkL(loxP/loxP)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-c9c5-f423-f162-a2b280000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    129/SvEv mouse ES cells were electroporated with a linearized targeting construct that contained the first exon of <i>CrkL</i>, flanked by two loxP sites, followed by a <i>NeoTK</i> gene and another loxP site. C57BL/6 × 129 chimeras were obtained. This line can be used to generate tissue-specific <i>CrkL</i> knockouts.
  2. Related Publication or Documentation
    Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway
  3. Related Publication or Documentation
    Cardiovascular and craniofacial defects in Crk-null mice
  4. Parental Strain Name
    C57BL/6 x 129
  5. Genetic Alteration(s)
    Floxed CrkL
  6. Location
    Curran Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-02-11T10:01:27.102-05:00
  4. creator
    fcoldren
  5. modified
    2013-02-20T16:02:46.015-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016