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Crk(loxP/loxP);CrkL(loxP/loxP);Nestin-Cre
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013c-c9cd-7b33-f162-a2b280000000
Resource Type
Properties
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Resource Description
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The <i>CrkL</i> floxed allele carries three loxP sites, since the <i>Neo</i>TK gene is present, whereas only two loxP sites, flanking the first exon, are present in the <i>Crk</i> floxed allele.
Crk is completely absent and CrkL expression is dramatically reduced in the cerebellum. Crk is not expressed in the hippocampus and CrkL expression decreased dramatically. Some cells, including pyramidal neurons in the CA3 region of the hippocampus, retained mild CrkL expression.
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Additional Name
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<i>Crk<sup>FL/FL</sup>;CrkL<sup>FL/FL</sup>;Nestin-Cre</i>
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Additional Name
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Neuron-specific <i>Crk</i> and <i>CrkL</i> knockout
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Additional Name
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dcKO
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Related Publication or Documentation
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Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway
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Parental Strain Name
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C57BL/6 x 129SvEv
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Biological process studied
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Brain development
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Genetic Alteration(s)
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Floxed Crk
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Genetic Alteration(s)
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Floxed CrkL
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Genetic Alteration(s)
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Nestin-Cre
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Phenotype Findings
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Small brain size
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Phenotype Findings
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Postnatal growth retardation
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Phenotype Findings
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Cerebellar hypofoliation
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Phenotype Findings
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Abnormal Purkinje cell migration
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Phenotype Findings
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Abnormal hippocampus pyramidal cell layer
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Phenotype Findings
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Abnormal cerebral cortex morphology
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Phenotype Findings
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Abnormal cortical lamination
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Phenotype Findings
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Abnormal dentate gyrus morphology
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Location
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0000013c-c9b4-7992-f162-a2b280000000
