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Chodosh Laboratory

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Resource Type

  1. Laboratory


  1. Resource Description
    "The Chodosh laboratory uses genetically engineered mouse models to study the genes and mechanisms that cause breast cancer and that regulate normal mammary gland development. The relationship between mammary development and breast cancer susceptibility is illustrated by the observation that women who have their first child early in life have a significantly lower lifetime risk of developing breast cancer. Understanding the molecular biology of breast cancer susceptibility requires a thorough understanding of the normal developmental biology of the mammary gland, the mechanisms by which breast cancers arise, and the role played by key regulatory molecules in each of these processes. Current experimental approaches towards these goals in the Chodosh laboratory include: 1. creating genetically engineered mouse models in which specific oncogenic pathways can be inducibly activated or repressed; 2. using <b>INDUCIBLE ANIMAL MODELS</b> to analyze the effect of developmental events on the mammary gland's response to a defined oncogenic stimulus; 3. using </b>INDUCIBLE ANIMAL MODELS</b> to dissect the process of carcinogenesis; 4. defining the molecular and cellular changes that occur in the mammary glands of mice, rats, and humans during <b>STAGES OF DEVELOPMENT THAT INFLUENCE BREAST CANCER RISK</b>; 5. using <b>GENOMIC AND COMPUTATIONAL APPROACHES</b> to investigate genetic programs in mammary development and carcinogenesis; and 6. studying the <b>FUNCTION OF THREE NOVEL SERINE/THREONINE KINASES IN MAMMARY DEVELOPMENT AND CARCINOGENESIS</b>. These approaches employ a variety of molecular, cellular, animal, human, and in silico model systems to study the function of key regulatory molecules in mammary gland biology."
  2. PI
    Chodosh, Lewis A., MD, PhD
  3. Affiliation
    Abramson Cancer Center
  4. Website(s)
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  2. contributor
    ggrant (Gregory Grant)
  3. created
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016