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Tg(TetO-Erbb2)1Lach

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-cf9d-3f6f-f162-a2b280000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "The transgene consists of the tet operator driving expression of a bicistronic transcript encoding activated rat Erbb2 (Neu), having the Val664Leu missense mutation, and firefly luciferase, the latter translated from an internal ribosome binding sequence (IRES) upstream of its coding sequence. In a mouse bitransgenic for this transgene and a tetracycline transactivator transgene, administration of doxycycline reversibly induces expression of Erbb2 and luciferase in tissues where the transactivator is expressed."
  2. Additional Name
    TAN
  3. Additional Name
    TetO-NeuNT
  4. Related Publication or Documentation
    Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis
  5. Website(s)
    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=34154
  6. Genetic Alteration(s)
    0000013c-cf90-34d3-f162-a2b280000000
  7. Location
    Chodosh Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    ggrant (Gregory Grant)
  3. created
    2013-02-12T13:14:54.096-05:00
  4. creator
    fcoldren
  5. modified
    2020-02-13T12:46:22.345-05:00
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016