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B6.Alb/cre,Pdss2(loxP/loxP)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-da26-9c98-f162-a2b280000000

Resource Type

  1. Mus musculus

Properties

  1. Related grant number
    RO1-DK55852
  2. Resource Description
    The <i>Pdss2</i> mutation was targeted to hepatocytes utilizing mice homozygous for the floxed gene (B6.<i>Pdss2<sup>loxP/loxP</sup></i>) crossed with partners that expressed cre under the control of an <i>albumin/cre</i> promoter (B6.Cg-Tg(<i>Alb-cre</i>)21 Mgn/J (<i>Alb/cre</i>)) obtained from The Jackson Laboratory.
  3. Additional Name
    Liver-conditional <i>Pdss2</i> knockout
  4. Related Disease
    interstitial nephritis
  5. Related Publication or Documentation
    Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice
  6. Related Publication or Documentation
    Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease
  7. Parental Strain Name
    C57BL/6J
  8. Genetic Alteration(s)
    Floxed Pdss2
  9. Genetic Alteration(s)
    Albumin/cre
  10. Phenotype Findings
    Hyperglycemia
  11. Phenotype Findings
    Blood ammonia level
  12. Phenotype Findings
    Hepatic function
  13. Phenotype Findings
    Hypercholesterolemia
  14. Phenotype Findings
    Respiratory chain function
  15. Phenotype Findings
    CoQ<sub>9</sub> deficiency
  16. Phenotype Findings
    Altered cellular metabolism
  17. Phenotype Findings
    Clinical manifestations of altered renal disease
  18. Location
    Gasser Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-02-14T14:21:03.970-05:00
  4. creator
    fcoldren
  5. modified
    2013-02-19T09:48:44.286-05:00

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