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MTS knockin mice
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013c-dab1-09e0-f162-a2b280000000
Resource Type
Properties
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Resource Description
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"Base pairs 1–105 of murine LAT cDNA were fused to LCP2 exon 1 and intron 1 DNA sequences. The LCP2 ATG was mutated, and the resulting fragment was cloned into the pPNT-FRT vector adjacent to the FRT-flanked neoR cassette. The targeting construct was electroporated into R1 embryonic stem cells, and injected into B6 × 129 blastocysts. The neoR cassette was excised by breeding to FLPe mice."
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Related Publication or Documentation
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Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production
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Related Publication or Documentation
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Cutting edge: rescue of pre-TCR but not mature TCR signaling in mice expressing membrane-targeted SLP-76
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Parental Strain Name
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B6.129
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Biological process studied
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Immune system process
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Genetic Alteration(s)
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Lcp2[tm5(Lat/Lcp2)Gak]
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Phenotype Findings
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Impaired T cell development
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Location
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Koretzky Laboratory
