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MTS knockin mice

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    "Base pairs 1–105 of murine LAT cDNA were fused to LCP2 exon 1 and intron 1 DNA sequences. The LCP2 ATG was mutated, and the resulting fragment was cloned into the pPNT-FRT vector adjacent to the FRT-flanked neoR cassette. The targeting construct was electroporated into R1 embryonic stem cells, and injected into B6 × 129 blastocysts. The neoR cassette was excised by breeding to FLPe mice."
  2. Related Publication or Documentation
    Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production
  3. Related Publication or Documentation
    Cutting edge: rescue of pre-TCR but not mature TCR signaling in mice expressing membrane-targeted SLP-76
  4. Parental Strain Name
  5. Biological process studied
    Immune system process
  6. Genetic Alteration(s)
  7. Phenotype Findings
    Impaired T cell development
  8. Location
    Koretzky Laboratory
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016