eagle-i The University of PennsylvaniaThe University of Pennsylvania
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

MTS knockin mice

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-dab1-09e0-f162-a2b280000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "Base pairs 1–105 of murine LAT cDNA were fused to LCP2 exon 1 and intron 1 DNA sequences. The LCP2 ATG was mutated, and the resulting fragment was cloned into the pPNT-FRT vector adjacent to the FRT-flanked neoR cassette. The targeting construct was electroporated into R1 embryonic stem cells, and injected into B6 × 129 blastocysts. The neoR cassette was excised by breeding to FLPe mice."
  2. Related Publication or Documentation
    Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production
  3. Related Publication or Documentation
    Cutting edge: rescue of pre-TCR but not mature TCR signaling in mice expressing membrane-targeted SLP-76
  4. Parental Strain Name
    B6.129
  5. Biological process studied
    Immune system process
  6. Genetic Alteration(s)
    Lcp2[tm5(Lat/Lcp2)Gak]
  7. Phenotype Findings
    Impaired T cell development
  8. Location
    Koretzky Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-02-14T16:52:09.508-05:00
  4. creator
    fcoldren
  5. modified
    2014-04-08T13:01:10.698-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016