eagle-i The University of PennsylvaniaThe University of Pennsylvania

Collapsing glomerulopathy

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-edbc-bcb5-f162-a2b280000000

Resource Type

  1. Mammal-specific phenotype

Properties

  1. Resource Description
    Diseased glomeruli show segmental and global sclerosis and collapse of capillary loops with folding and wrinkling of the glomerular basement membrane, extensive foot process effacement with marked condensation of the actin cytoskeleton and focal loss of primary processes of podocytes, and hyperplastic and hypertrophic podocytes with de novo cyclin D1, Ki-67, and desmin expression and reduced synaptopodin and WT-1 expression. In addition to these significant alterations to podocytes, focal injury to the parietal epithelium lining Bowman’s capsule is evident.
  2. Mammalian phenotype
    abnormal renal/urinary system morphology
 
RDFRDF
 
Provenance Metadata About This Resource Record
    Copyright © 2016 by the President and Fellows of Harvard College
    The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016