Collapsing glomerulopathy

eagle-i ID

Resource Type

Properties

1. Resource Description

   Diseased glomeruli show segmental and global sclerosis and collapse of capillary loops with folding and wrinkling of the glomerular basement membrane, extensive foot process effacement with marked condensation of the actin cytoskeleton and focal loss of primary processes of podocytes, and hyperplastic and hypertrophic podocytes with de novo cyclin D1, Ki-67, and desmin expression and reduced synaptopodin and WT-1 expression. In addition to these significant alterations to podocytes, focal injury to the parietal epithelium lining Bowman’s capsule is evident.

2. Mammalian phenotype

   abnormal renal/urinary system morphology