Renal disease prevented

eagle-i ID

Resource Type

Properties

1. Resource Description

   Probucol therapy (1% in standard mouse chow) significantly prevents renal disease whether administered from the time of weaning through at least 6 months of age or for only approximately 3 weeks prior to sacrifice. While all of the probucol-treated missense mutant groups show significantly higher urine albumin than gender-matched healthy B6 controls, no significant differences are seen in their mean nephritis score relative to gender-matched healthy B6 controls (p > 0.05).

2. Mammalian phenotype

   phenotypic reversion