eagle-i The University of PennsylvaniaThe University of Pennsylvania

Renal disease prevented

eagle-i ID


Resource Type

  1. Mammal-specific phenotype


  1. Resource Description
    Probucol therapy (1% in standard mouse chow) significantly prevents renal disease whether administered from the time of weaning through at least 6 months of age or for only approximately 3 weeks prior to sacrifice. While all of the probucol-treated missense mutant groups show significantly higher urine albumin than gender-matched healthy B6 controls, no significant differences are seen in their mean nephritis score relative to gender-matched healthy B6 controls (p > 0.05).
  2. Mammalian phenotype
    phenotypic reversion
Provenance Metadata About This Resource Record
    Copyright © 2016 by the President and Fellows of Harvard College
    The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016