eagle-i The University of PennsylvaniaThe University of Pennsylvania

Hyperlipidemia

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-ee00-ab19-f162-a2b280000000

Resource Type

  1. Biological process phenotype

Properties

  1. Resource Description
    At 152 ± 16 days of age, serum triglyceride and cholesterol levels are significantly higher than in B6 controls. Very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL) and high density lipoprotein (HDL) levels increase. The greatest increase is in the HDL-bound fraction, typical of nephrotic mice. This is in contrast to what would be observed in humans, as the lipid profile of mice is quite different from that of humans, since cholesterol circulates mostly as HDL cholesterol in mice.
  2. Resource Description
    Probucol treatment significantly reduces liver membrane phospholipids, including cardiolipin, sphingomyelin and phospholipids, and plasma cholesterol and triglyceride levels relative to untreated littermates.
  3. Biological process
    Response to chemical stimulus
  4. Descriptor
    increased process quality
 
RDFRDF
 
Provenance Metadata About This Resource Record
    Copyright © 2016 by the President and Fellows of Harvard College
    The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016