eagle-i The University of PennsylvaniaThe University of Pennsylvania

CoQ level in tissues

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-ee0c-0307-f162-a2b280000000

Resource Type

  1. Mammal-specific phenotype

Properties

  1. Resource Description
    At 75 days of age, the content of Q<sub>9</sub> and Q<sub>10</sub> in kidney lipid content is significantly lower than wild-type littermates and fails to increase with age. A similar trend was observed in liver.
  2. Resource Description
    Chronic probucol supplementation, chow supplemented with probucol from birth to age 207 days, significantly elevated total CoQ content in the liver. Both CoQ<sub>9</sub> and CoQ<sub>10</sub> were approximately two-fold greater in females than males at baseline and increased following long-term probucol treatment in both genders.
  3. Resource Description
    Short-term (15 day) probucol treatment in mice showing albuminuria resulted in elevated total CoQ<sub>9</sub> and marginally increased total CoQ<sub>10</sub> in the kidney. No significant differences in CoQ<sub>9</sub> or CoQ<sub>10</sub> levels were observed in liver.
  4. Mammalian phenotype
    abnormal kidney physiology
 
RDFRDF
 
Provenance Metadata About This Resource Record
    Copyright © 2016 by the President and Fellows of Harvard College
    The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016