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rl/rl ne-reelin

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013c-f3ac-e285-f162-a2b280000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Myc-tagged <i>reelin</i> under the control of the rat <i>nestin</i> intermediate-filament gene promoter was introduced into fertilized one-cell FvB mouse embryos by microinjection. <i>Ne-reelin</i> mice (strain FvB) were bred to <i>reeler</i> mice (strain B6C3Fe) from the Jackson Laboratory to generate mice that were transgenic for <i>ne-reelin</i> and mutant for <i>reelin</i>. Mice carrying <i>ne-reelin</i> express an additional source of reelin mRNA throughout the ventricular zone of the forebrain, midbrain, and cerebellum at E16.5.
  2. Related Publication or Documentation
    Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord
  3. Related Publication or Documentation
    Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice
  4. Parental Strain Name
    FVB x B57BL6
  5. Biological process studied
    Brain development
  6. Genetic Alteration(s)
    Ne-reelin
  7. Genetic Alteration(s)
    Reeler
  8. Phenotype Findings
    Normal cortical plate structure
  9. Phenotype Findings
    Abnormal cerebral cortex morphology
  10. Phenotype Findings
    Abnormal cerebellar foliation
  11. Phenotype Findings
    Normal locomotion
  12. Phenotype Findings
    Fertility
  13. Phenotype Findings
    Tremors
  14. Phenotype Findings
    Abnormal neuronal migration
  15. Location
    Curran Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-02-19T13:18:19.465-05:00
  4. creator
    fcoldren
  5. modified
    2013-02-20T16:14:00.536-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016