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rl/rl ne-reelin
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013c-f3ac-e285-f162-a2b280000000
Resource Type
Properties
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Resource Description
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Myc-tagged <i>reelin</i> under the control of the rat <i>nestin</i> intermediate-filament gene promoter was introduced into fertilized one-cell FvB mouse embryos by microinjection. <i>Ne-reelin</i> mice (strain FvB) were bred to <i>reeler</i> mice (strain B6C3Fe) from the Jackson Laboratory to generate mice that were transgenic for <i>ne-reelin</i> and mutant for <i>reelin</i>.
Mice carrying <i>ne-reelin</i> express an additional source of reelin mRNA throughout the ventricular zone of the forebrain, midbrain, and cerebellum at E16.5.
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Related Publication or Documentation
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Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord
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Related Publication or Documentation
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0000013c-c9e2-1dfb-f162-a2b280000000
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Parental Strain Name
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FVB x B57BL6
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Biological process studied
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Brain development
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Genetic Alteration(s)
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Ne-reelin
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Genetic Alteration(s)
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Reeler
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Phenotype Findings
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Normal cortical plate structure
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Phenotype Findings
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Abnormal cerebral cortex morphology
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Phenotype Findings
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Abnormal cerebellar foliation
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Phenotype Findings
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Normal locomotion
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Phenotype Findings
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Fertility
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Phenotype Findings
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Tremors
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Phenotype Findings
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Abnormal neuronal migration
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Location
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0000013c-c9b4-7992-f162-a2b280000000
