rl/rl ne-reelin

eagle-i ID

Resource Type

Properties

1. Resource Description

   Myc-tagged <i>reelin</i> under the control of the rat <i>nestin</i> intermediate-filament gene promoter was introduced into fertilized one-cell FvB mouse embryos by microinjection. <i>Ne-reelin</i> mice (strain FvB) were bred to <i>reeler</i> mice (strain B6C3Fe) from the Jackson Laboratory to generate mice that were transgenic for <i>ne-reelin</i> and mutant for <i>reelin</i>. Mice carrying <i>ne-reelin</i> express an additional source of reelin mRNA throughout the ventricular zone of the forebrain, midbrain, and cerebellum at E16.5.

2. Related Publication or Documentation

   Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord

3. Related Publication or Documentation

   Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice

4. Parental Strain Name

   FVB x B57BL6

5. Biological process studied

   Brain development

6. Genetic Alteration(s)

   Ne-reelin

7. Genetic Alteration(s)

   Reeler

8. Phenotype Findings

   Normal cortical plate structure

9. Phenotype Findings

   Abnormal cerebral cortex morphology

10. Phenotype Findings

    Abnormal cerebellar foliation

11. Phenotype Findings

    Normal locomotion

12. Phenotype Findings

    Fertility

13. Phenotype Findings

    Tremors

14. Phenotype Findings

    Abnormal neuronal migration

15. Location

    Curran Laboratory