eagle-i The University of PennsylvaniaThe University of Pennsylvania
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

rl/rl ne-reelin

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    Myc-tagged <i>reelin</i> under the control of the rat <i>nestin</i> intermediate-filament gene promoter was introduced into fertilized one-cell FvB mouse embryos by microinjection. <i>Ne-reelin</i> mice (strain FvB) were bred to <i>reeler</i> mice (strain B6C3Fe) from the Jackson Laboratory to generate mice that were transgenic for <i>ne-reelin</i> and mutant for <i>reelin</i>. Mice carrying <i>ne-reelin</i> express an additional source of reelin mRNA throughout the ventricular zone of the forebrain, midbrain, and cerebellum at E16.5.
  2. Related Publication or Documentation
    Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord
  3. Related Publication or Documentation
    Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice
  4. Parental Strain Name
    FVB x B57BL6
  5. Biological process studied
    Brain development
  6. Genetic Alteration(s)
  7. Genetic Alteration(s)
  8. Phenotype Findings
    Normal cortical plate structure
  9. Phenotype Findings
    Abnormal cerebral cortex morphology
  10. Phenotype Findings
    Abnormal cerebellar foliation
  11. Phenotype Findings
    Normal locomotion
  12. Phenotype Findings
  13. Phenotype Findings
  14. Phenotype Findings
    Abnormal neuronal migration
  15. Location
    Curran Laboratory
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
  3. created
  4. creator
  5. modified

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016