ErythronDB

eagle-i ID

Resource Type

Properties

1. Related grant number

   NIDDK R01 DK 071116

2. Related Software

   Strategies WDK

3. Resource Description

   "The ErythronDB project is the result of a collaboration between the <b>Palis Lab (University of Rochester)</b> and the <b>Stoeckert Lab (University of Pennsylvania)</b>. The laboratory of Dr. Palis brings expertise in the cellular and molecular events underlying the ontogeny of hematopoiesis in the mammalian embryo. The laboratory of Dr. Stoeckert contributes state of the art computational and bioinformatics expertise. The Erythron Database is a resource dedicated to facilitating better understanding of the cellular and molecular underpinnings of mammalian erythropoiesis. The resource is built upon a searchable database of gene expression in murine primitive and definitive erythroid cells at progressive stages of maturation. ErythronDB allows users to identify sets of genes that are differentially expressed or exhibit similar levels or patterns of mRNA expression during erythrocyte development. Searches are also available for exploring networks of gene-interactions inferred from annotated expression data. All ErythronDB strategies can easily be refined and expanded using the Strategies interface. Register to save and share strategies with others. Registration also provides access to a Basket, which allows users to interactively assemble a list of genes of interest from search strategy results." Members from the <b>Palis Lab in the Department of Pediatrics, University of Rochester Medical Center</b> that developed ErythronDB are Paul D. Kingsley, Ph.D.; Jenna M. Frame, M.S.; Timothy P. Bushnell, Ph.D.; Jeffrey Malik, Ph.D.; Kathleen E. McGrath, Ph.D.; and James Palis, M.D..

4. Used by

   Computational Biology and Informatics Laboratory

5. Operating System

   Web based

6. Data Input

   Gene expression data from all three lineages of murine erythropoiesis

7. Topic

   Mus musculus

8. Topic

   Erythropoiesis

9. Related Publication or Documentation

   Ontogeny of erythroid gene expression

10. Related Publication or Documentation

    Stat and interferon genes identified by network analysis differentially regulate primitive and definitive erythropoiesis

11. Website(s)

    http://www.cbil.upenn.edu/ErythronDB/

12. Developed by

    Stoeckert, Christian J., Jr., Ph.D.

13. Developed by

    Greenfest-Allen, Emily, Ph.D.