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fP(fl/fl);Lys-Cre

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013d-c6a5-7c41-2ed7-105480000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    <i>Cfp<sup>fl/fl</sup></i> mice were crossed with lysozyme-Cre (Lys-Cre) transgenic mice, which express the Cre recombinase specifically in myeloid lineage cells.
  2. Additional Name
    Cfp(fl/fl);Lys-Cre
  3. Additional Name
    Myeloid lineage cell-specific <i>Cfp</i> knockout
  4. Related Publication or Documentation
    Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury
  5. Related Publication or Documentation
    Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice
  6. Parental Strain Name
    mixed C57BL/6-129J
  7. Biological process studied
    Immune response
  8. Genetic Alteration(s)
    Lyz2[tm1(cre)Ifo]
  9. Genetic Alteration(s)
    Cfp[tm2.1Song]
  10. Phenotype Findings
    Reduced plasma properdin level
  11. Phenotype Findings
    Reduced AP complement activity
  12. Phenotype Findings
    Attenuated disease in K/BxN model of arthritis
  13. Location
    Wen-Chao Song Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-04-01T13:33:19.169-04:00
  4. creator
    fcoldren
  5. modified
    2016-02-17T17:30:36.724-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016