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C3.B6-ByBir-gus[mps]

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013d-cbde-65d4-2ed7-105480000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    This strain is generated from the backcross of C57BL/6.C-<i>H-2<sup>bm1</sup></i>/ByBir-<i>gus<sup>mps</sup></i> mice onto the C3H-HeOuJ strain.
  2. Additional Name
    C3.B6-<i>gus<sup>mps</sup></i>
  3. Related Disease
    Sly syndrome
  4. Related Disease
    lysosomal storage disease
  5. Related Publication or Documentation
    Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology
  6. Related Publication or Documentation
    Selective neurodegeneration in murine mucopolysaccharidosis VII is progressive and reversible
  7. Related Publication or Documentation
    Variant clinical course of mucopolysaccharidosis type VII in two groups of mice carrying the same mutation
  8. Related Publication or Documentation
    High-Resolution Magnetic Resonance Microscopy and Diffusion Tensor Imaging to Assess Brain Structural Abnormalities in the Murine Mucopolysaccharidosis VII Model
  9. Genetic Alteration(s)
    gus[mps]
  10. Phenotype Findings
    Astrogliosis
  11. Phenotype Findings
    Facial dysmorphia
  12. Phenotype Findings
    Decreased body weight
  13. Phenotype Findings
    Normal mobility at weaning, but decreased mobility with age
  14. Phenotype Findings
    Life span
  15. Phenotype Findings
    MPS VII phenotype
  16. Phenotype Findings
    Shortened and thickened bones
  17. Phenotype Findings
    Vacuolization
  18. Location
    Wolfe Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-04-02T13:49:55.054-04:00
  4. creator
    fcoldren
  5. modified
    2014-01-06T11:30:33.710-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016