Storage lesions

eagle-i ID

Resource Type

Properties

1. Resource Description

   At E18.5 storage lesions were seen in perivascular areas near the meninges of the brain, but the vacuoles were few in number and were only detected in a small number of cells. Vacuolation was more prominent in the brain by birth. At 5 months of age, storage lesions were evident in regions that contained abundant ubiquitin-immunoreactive lesions including the oriens layer and cerebral cortex.

2. Mammalian phenotype

   abnormal brain morphology