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eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    This line was generated by the group of Fred Gage at The Salk Institute for Biological Studies. Exons 2 through 10 were replaced by homologous recombination of a targeting vector containing lacZ and neo. The deleted region encoded the MBD1, CXXC1, CXXC2, and CXXC3 domains. LInearized targeting vector was electroporated into J1 embryonic stem cells. ES clones were injected into C57BL/6 blastocysts. MBD1<sup>+/-</sup> mice were generated by crossing chimeric mice with 129S4 (formerly 129/SvJae) females to generate MBD<sup>+/-</sup> F1 litters, which contain a 129S4 genetic background. Crossing F1 MBD<sup>+/-</sup> mice generated F2 MBD<sup>-/-</sup> mice.
  2. Additional Name
  3. Related Publication or Documentation
    Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function
  4. Genetic Alteration(s)
  5. Phenotype Findings
    Deficits in neurogenesis and hippocampal function
  6. Phenotype Findings
    Autism-like behavior
  7. Location
    Bartolomei Laboratory
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016