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eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    This line was generated by the group of Adrian Bird. Exon 2 of the <i>Mbd2</i> gene was replaced with the promoterless beta-geo cassette. The resulting transcript can encode the N-terminal 183 amino acids of MBD2, but translation then stops in the middle of the methyl-CpG binding domain. Gene targeting was performed in the ES cell line E14 TG2a, which is derived from the mouse substrain 129/Ola. ES cells were transfected with the linearized targeting vector by electroporation. Targeted ES cells were injected into C57BL/6 blastocysts. Chimeric pups were mated with C57BL/6 mice.
  2. Related Publication or Documentation
    Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development
  3. Genetic Alteration(s)
  4. Phenotype Findings
    Abnormal maternal behavior
  5. Location
    Bartolomei Laboratory
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016