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B6.Cg-Apobec3Gt(XN450)Byg

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013e-22b8-8081-2ed7-105480000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "ES cell line XN450 with the gene trap vector in intron 4 of the mouse APOBEC3 (mA3) gene was obtained from BayGenomics Gene Trap Project (http://baygenomiccs.ucsf.edu) and injected into the blastocysts by Transgenic Knockout Shared Resource at UC Davis Mouse Biology Program, Davis, CA, to create chimeric mice. Chimeric mice were backcrossed to C57BL/6J mice (Jackson Laboratory, Jackson, ME) for nine generations and heterozygotes were crossed with each other to generate A3 -/- mice. Heterozygous mice were generated by crossing A3 -/- to C57BL/6J mice."
  2. Additional Name
    mA3<sup>-/-</sup>
  3. Related Publication or Documentation
    APOBEC3 inhibits mouse mammary tumour virus replication in vivo
  4. Parental Strain Name
    C57BL/6J
  5. Biological process studied
    Response to virus
  6. Genetic Alteration(s)
    Apobec3[Gt(XN450)Byg]
  7. Phenotype Findings
    Increased susceptibility to viral infection
  8. Phenotype Findings
    Increased activated B and T cell number
  9. Location
    Ross Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-04-19T10:35:41.681-04:00
  4. creator
    fcoldren
  5. modified
    2013-04-19T15:33:49.293-04:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016