eagle-i The University of PennsylvaniaThe University of Pennsylvania
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Dfmr1[3] null

eagle-i ID


Resource Type

  1. Drosophila melanogaster


  1. Resource Description
    This stock contains a deletion of the <i>dfmr1</i> gene as described in, "Drosophila Lacking dfmr1 Activity Show Defects in Circadian Output and Fail to Maintain Courtship Interest." The mutants are viable but display defects in several neurons and behavioral test including naïve courtship, memory and circadian behavior.
  2. Additional Name
    <i>Drosophila</i> Fragile X Syndrome model
  3. Related Disease
    chromosomal disease
  4. Related Disease
    fragile X syndrome
  5. Related Disease
    nervous system disease
  6. Related Publication or Documentation
    Drosophila lacking dfmr1 activity show defects in circadaian output and fail to maintain courtship interest
  7. Related Publication or Documentation
    Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome
  8. Related Publication or Documentation
    Age-dependent cognitive impairment in a Drosophila fragile X model and its pharmacological rescue
  9. Website(s)
  10. Related Technique
    Behavioral assay
  11. Biological process studied
  12. Biological process studied
  13. Biological process studied
    Courtship behavior
  14. Biological process studied
    circadian rhythm
  15. Genetic Alteration(s)
  16. Phenotype Findings
    Courtship behavior defective in male flies
  17. Phenotype Findings
    Eclosion rhythm defective
  18. Phenotype Findings
    Locomotor rhythm defective
  19. Phenotype Findings
  20. Phenotype Findings
    Abnormal lateral neuron projections
  21. Location
    Thomas Jongens Laboratory
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016