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Dfmr1[3] null

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013e-57d1-0dc3-2f2e-ad3380000000

Resource Type

  1. Drosophila melanogaster

Properties

  1. Resource Description
    This stock contains a deletion of the <i>dfmr1</i> gene as described in, "Drosophila Lacking dfmr1 Activity Show Defects in Circadian Output and Fail to Maintain Courtship Interest." The mutants are viable but display defects in several neurons and behavioral test including naïve courtship, memory and circadian behavior.
  2. Additional Name
    <i>Drosophila</i> Fragile X Syndrome model
  3. Related Disease
    chromosomal disease
  4. Related Disease
    fragile X syndrome
  5. Related Disease
    nervous system disease
  6. Related Publication or Documentation
    Drosophila lacking dfmr1 activity show defects in circadaian output and fail to maintain courtship interest
  7. Related Publication or Documentation
    Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome
  8. Related Publication or Documentation
    Age-dependent cognitive impairment in a Drosophila fragile X model and its pharmacological rescue
  9. Website(s)
    http://flybase.org/reports/FBal0137500.html
  10. Related Technique
    Behavioral assay
  11. Biological process studied
    Behavior
  12. Biological process studied
    memory
  13. Biological process studied
    Courtship behavior
  14. Biological process studied
    circadian rhythm
  15. Genetic Alteration(s)
    Fmr1[3]
  16. Phenotype Findings
    Courtship behavior defective in male flies
  17. Phenotype Findings
    Eclosion rhythm defective
  18. Phenotype Findings
    Locomotor rhythm defective
  19. Phenotype Findings
    viable
  20. Phenotype Findings
    Abnormal lateral neuron projections
  21. Location
    Thomas Jongens Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016