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C5aR(-/-)
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013e-57e4-249c-2f2e-ad3380000000
Resource Type
Mus musculus
Properties
Resource Description
A breeder pair of C5a receptor knockout (C5aR<sup>−/−</sup>) mice on the C57BL/6 background was provided by Dr. J. Lambris. In these mice, "A PGK-neomycin resistance cassette replaced the entire coding region of the gene."
Additional Name
C5aR KO
Access Restriction(s)
MTA restrictions
Related Publication or Documentation
Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production
Related Publication or Documentation
Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice
Related Publication or Documentation
Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice
Related Publication or Documentation
C5aR expression in a novel GFP reporter gene knockin mouse: implications for the mechanism of action of C5aR signaling in T cell immunity
Related Publication or Documentation
Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo
Website(s)
http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=3284
Parental Strain Name
C57BL/6
Biological process studied
Immune system process
Genetic Alteration(s)
C5ar1[tm1Cge]
Phenotype Findings
Abnormal complement pathway
Location
Wen-Chao Song Laboratory
Inferred Types from the eagle-i Ontology (
What is an ontology?
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entity
continuant
independent_continuant
material_entity
Organism
Mus <mouse, genus>
Glires
Mammalia
Chordata
Vertebrata <Metazoa>
Rodentia
Organism or Virus
Thing
Provenance Metadata About This Resource Record
workflow state
Published
contributor
fcoldren
created
2013-04-29T18:24:58.404-04:00
creator
fcoldren
modified
2016-02-17T17:08:24.820-05:00