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C5aR(-/-)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013e-57e4-249c-2f2e-ad3380000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    A breeder pair of C5a receptor knockout (C5aR<sup>−/−</sup>) mice on the C57BL/6 background was provided by Dr. J. Lambris. In these mice, "A PGK-neomycin resistance cassette replaced the entire coding region of the gene."
  2. Additional Name
    C5aR KO
  3. Access Restriction(s)
    MTA restrictions
  4. Related Publication or Documentation
    Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production
  5. Related Publication or Documentation
    Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice
  6. Related Publication or Documentation
    Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice
  7. Related Publication or Documentation
    C5aR expression in a novel GFP reporter gene knockin mouse: implications for the mechanism of action of C5aR signaling in T cell immunity
  8. Related Publication or Documentation
    Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo
  9. Website(s)
    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=3284
  10. Parental Strain Name
    C57BL/6
  11. Biological process studied
    Immune system process
  12. Genetic Alteration(s)
    C5ar1[tm1Cge]
  13. Phenotype Findings
    Abnormal complement pathway
  14. Location
    Wen-Chao Song Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-04-29T18:24:58.404-04:00
  4. creator
    fcoldren
  5. modified
    2016-02-17T17:08:24.820-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016