C5aR(-/-)

eagle-i ID

Resource Type

Properties

1. Resource Description

   A breeder pair of C5a receptor knockout (C5aR^−/−) mice on the C57BL/6 background was provided by Dr. J. Lambris. In these mice, "A PGK-neomycin resistance cassette replaced the entire coding region of the gene."

2. Additional Name

   C5aR KO

3. Access Restriction(s)

   MTA restrictions

4. Related Publication or Documentation

   Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production

5. Related Publication or Documentation

   Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice

6. Related Publication or Documentation

   Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice

7. Related Publication or Documentation

   C5aR expression in a novel GFP reporter gene knockin mouse: implications for the mechanism of action of C5aR signaling in T cell immunity

8. Related Publication or Documentation

   Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo

9. Website(s)

   http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=3284

10. Parental Strain Name

    C57BL/6

11. Biological process studied

    Immune system process

12. Genetic Alteration(s)

    C5ar1[tm1Cge]

13. Phenotype Findings

    Abnormal complement pathway

14. Location

    Wen-Chao Song Laboratory