DAF(-/-)/C3(-/-)

eagle-i ID

Resource Type

Properties

1. Resource Description

   DAF^-/- mice were crossed with C3^-/- mice.

2. Additional Name

   CD55(-/-)/C3(-/-)

3. Related Publication or Documentation

   Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice

4. Related Publication or Documentation

   Decay-accelerating factor regulates T-cell immunity in the context of inflammation by influencing costimulatory molecule expression on antigen-presenting cells

5. Related Publication or Documentation

   Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo

6. Related Publication or Documentation

   Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg

7. Related Publication or Documentation

   Retrovirus-mediated over-expression of decay-accelerating factor rescues Crry-deficient erythrocytes from acute alternative pathway complement attack

8. Biological process studied

   Immune system process

9. Genetic Alteration(s)

   CD55[tm1Song]

10. Genetic Alteration(s)

    C3[tm1Hrc]

11. Phenotype Findings

    Response to antigen restimulation

12. Phenotype Findings

    Experimental autoimmune encephalomyelitis phenotype

13. Phenotype Findings

    Normal cytokine level

14. Phenotype Findings

    Response to acute LCMV infection

15. Location

    Wen-Chao Song Laboratory